解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Assays to evaluate platelet function are often interchangeably used to assess "resistance" to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin. DESIGN AND METHODS:Platelet function was evaluated in 162 subjects, 85 of whom were not being treated with any ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.027102
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear. DESIGN AND METHODS:Hepcidin expression, SMAD and extracellular signa...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.027003
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Chronic lymphocytic leukemia has a variable clinical course. Genomic aberrations identify prognostic subgroups, pointing towards distinct underlying biological mechanisms that are poorly understood. In particular it remains unclear whether the prognostic subgroups of chronic lymphocytic leukemia are characte...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.025734
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders with a high propensity to transform into acute myeloid leukemia. Heterozygous missense mutations in IDH1 at position R132 and in IDH2 at positions R140 and R172 have recently been reported in acute myeloid leukemia. Howe...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.025494
更新日期:2010-10-01 00:00:00
abstract::Pseudomonas aeruginosa is one leading gram-negative organism associated with nosocomial infections. Bacteremia is life-threatening in the immunocompromised host. Increasing frequency of multi-drug-resistant (MDRPA) strains is concerning. We started a retrospective survey in the pediatric hematology oncology Italian ne...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2009.020867
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor. Hereditary type I protein S deficiency (low total and low free protein S) is a well-established risk factor for venous thrombosis, whereas t...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.021923
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Diamond-Blackfan anemia is a rare, clinically heterogeneous, congenital red cell aplasia: 40% of patients have congenital abnormalities. Recent studies have shown that in western countries, the disease is associated with heterozygous mutations in the ribosomal protein (RP) genes in about 50% of patients. The...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2009.020826
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Usefulness of iron chelation therapy in myelodysplastic patients is still under debate but many authors suggest its possible role in improving survival of low-risk myelodysplastic patients. Several reports have described an unexpected effect of iron chelators, such as an improvement in hemoglobin levels, in ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.016824
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin. In the plas...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.020123
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Vgamma9Vdelta2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vgamma9Vdelta2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.020602
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Children with Down syndrome have an increased risk of developing acute lymphoblastic leukemia and a poor tolerance of methotrexate. This latter problem is assumed to be caused by a higher cellular sensitivity of tissues in children with Down syndrome. However, whether differences in pharmacokinetics play a r...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.019778
更新日期:2010-07-01 00:00:00
abstract::The causes of myeloproliferative neoplasm (MPN) are unknown. We conducted a large population-based study including 11,039 myeloproliferative neoplasm patients and 43,550 matched controls with the aim of assessing the associations between a personal history of a broad span of autoimmune diseases and subsequent risk of ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.020412
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and survival. DESIGN AND ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.013847
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:There is little published information on the everyday clinical management of myelodysplastic syndromes in real world practice. DESIGN AND METHODS:We conducted a cross-sectional study of all patients with myelodysplastic syndromes attending 74 French centers in a 1-week period for inpatient admission, day-ho...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2009.014357
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The hemangioblast is a bi-potential precursor cell with the capacity to differentiate into hematopoietic and vascular cells. In mouse E7.0-7.5 embryos, the hemangioblast can be identified by a clonal blast colony-forming cell (BL-CFC) assay or single cell OP9 co-culture. However, the ontogeny of the hemangio...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.014241
更新日期:2010-06-01 00:00:00
abstract::Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder which is due to a mutation in the gene encoding for platelet glycoprotein Ibalpha (GPIbalpha) resulting in enhanced affinity for von Willebrand factor (VWF). PT-VWD is often mistakenly diagnosed as type 2B VWD for the similari...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.015990
更新日期:2010-06-01 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN. However, it is not clear whether NOTCH1 mutations associate with decreased PTEN expression in primary T-ALL. Here, we compared patients with or wi...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.011999
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS:We studied 23 patients with PNH, before and after five and 11 weeks of treatment with eculizumab. We examined markers of thrombin generation and reactional fibrinolysis...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2009.016121
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Hematocrit above the normal range for the population, such as in primary or secondary erythrocytosis, predisposes to both arterial and venous thrombosis. However, little is known about the association between hematocrit and risk of venous thromboembolism in a general population. DESIGN AND METHODS:Hematocri...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.008417
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The histone deacetylase inhibitor ITF2357 has potent cytotoxic activity in multiple myeloma in vitro and has entered clinical trials for this disease. DESIGN AND METHODS:In order to gain an overall view of the activity of ITF2357 and identify specific pathways that may be modulated by the drug, we performed...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.012088
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Transcription factors play essential roles in both normal and malignant hematopoiesis. This is the case for the growth factor independent 1b (GFI1B) transcription factor, which is required for erythroid and megakaryocytic differentiation and over-expressed in leukemic patients and cell lines. DESIGN AND MET...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.012351
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data. This is also true for immunohistochemical classifiers that are thought to reflect the cell-of-origin subclassification of gene expression stu...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.008862
更新日期:2009-11-01 00:00:00
abstract::To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.007708
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Chronic myeloid leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22, creating the fusion gene BCR-ABL. The clinical significance of the type of BCR-ABL transcript in newly diagnosed patients in chronic phase treated with imatinib 400 mg from initial diagnosis remains unknown....
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2009.009134
更新日期:2009-10-01 00:00:00
abstract::To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.008508
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:beta-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate beta-globin chain production. The excessive unbound alpha-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis. DESIGN AND METHODS:I...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.005827
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Granulocyte colony-stimulating factor mobilized peripheral blood stem cells are increasingly used instead of bone marrow as a stem cell source for transplantation. Whereas this change is almost complete for autologous transplantation, there are some concerns when considering allogeneic transplants. DESIGN A...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2009.006924
更新日期:2009-09-01 00:00:00
abstract::The dic(9;20)(p11-13;q11) is a recurrent chromosomal abnormality in patients with acute lymphoblastic leukemia. Although it results in loss of material from 9p and 20q, the molecular targets on both chromosomes have not been fully elucidated. From an initial cohort of 58 with acute lymphoblastic leukemia patients with...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.002808
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRbeta (TPbeta, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRalpha (FPalpha) results from a deletion on chromosome 4q12 and ZNF19...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.001149
更新日期:2009-08-01 00:00:00
abstract::Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmun...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2009.005983
更新日期:2009-08-01 00:00:00
abstract::High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation has been shown to result in durable hematologic response and prolonged overall survival in systemic AL amyloidosis. In this retrospective study, we evaluated clinical and hematologic responses in 69 patients with predominant liv...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.001925
更新日期:2009-07-01 00:00:00
abstract::Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.000034
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD). DESIGN AND METHODS:Eight patients from three unrelated families with this mutation were included in the present study who had distinct VWF abnormalities, not descr...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.003301
更新日期:2009-05-01 00:00:00
abstract::We studied the impact of comorbidities on survival and evaluated the prognostic utility of comorbidity scores in MDS patients, who received best supportive care and were assessable according to the Charlson Comorbidity Index (CCI) and the Hematopoietic Stem Cell Transplantation Comorbidity Index (HCTCI): 171 patients ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.002063
更新日期:2009-05-01 00:00:00
abstract::JAK2 V617F, identified in the majority of patients with myeloproliferative neoplasms, tyrosine phosphorylates SOCS3 and escapes its inhibition. Here, we demonstrate that the JAK2 exon 12 mutants described in a subset of V617F-negative MPN cases, also stabilize tyrosine phosphorylated SOCS3. SOCS3 tyrosine phosphorylat...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.002352
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Light chain amyloidosis is a rare plasma cell dyscrasia. Interphase fluorescence in situ hybridization (FISH) coupled to cytoplasmic staining of specific Ig (cIg-FISH) on bone marrow plasma cells has become well established in the initial evaluation of multiple myeloma, a related disorder. Little, however, i...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.13369
更新日期:2009-03-01 00:00:00
abstract::Acute myeloid leukemia carrying cytoplasmic mutated nucleophosmin (NPMc(+) AML) and blastic plasmacytoid dendritic cell neoplasm have been included as new entities in the 4(th) edition (2008) WHO classification of myeloid neoplasms. These conditions may show clinical and pathological overlapping features (leukemic and...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.13855
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia is a clonal hematopoietic malignant disease; about 45-50% of cases do not have detectable chromosomal abnormalities. Here, we identified hidden genomic alterations and novel disease-related regions in normal karyotype acute myeloid leukemia/myelodysplastic syndrome samples. DESIGN AND...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.13024
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:The risk for donors of allogeneic hematopoietic stem cells transplants is generally considered negligible. Scattered reports of severe complications and a recent controversy on hematopoietic malignancies after granulocyte colony-stimulating factor administration have challenged this opinion. DESIGN AND METH...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.13668
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Many different techniques have been designed for the quantification of JAK2V617F allelic burden, sometimes producing discrepant results. DESIGN AND METHODS:JAK2V617F quantification techniques were compared among 16 centers using 11 assays based on quantitative polymerase chain reaction (with mutation-specif...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.13486
更新日期:2009-01-01 00:00:00